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CD8 Antibody (C8/468 + C8/144B), Alexa Fluor™ 405, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP234590AF405
Description
CD8 Monoclonal specifically detects CD8 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.Specifications
CD8 | |
Monoclonal | |
Alexa Fluor 405 | |
CD8, CD8a molecule, LEU2, p32 | |
Mouse | |
32 kDa | |
0.1 mL | |
Adaptive Immunity, Cytokine Research, Immunology, Innate Immunity, Signal Transduction, Stem Cell Markers | |
925 | |
Human | |
Purified |
Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) | |
C8/468 + C8/144B | |
Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen | |
CD8A | |
Human CD8 recombinant protein (C8/468); A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of alpha chain of human CD8 molecule (C8/144B) (Uniprot: P01732) | |
Protein A or G purified | |
RUO | |
Primary | |
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. | |
Store at 4C in the dark. | |
IgG1 κ |
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