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CD8 Mouse anti-Human, Alexa Fluor 488, Clone: SPM548, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP234790AF488

Catalog No. NBP234790X


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Description

Description

CD8 Monoclonal antibody specifically detects CD8 in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen).
Specifications

Specifications

CD8
SPM548
Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Purified
CD8A
Human CD8 recombinant protein
32 kDa
0.1 ml
Adaptive Immunity, Cytokine Research, Immunology, Innate Immunity, Signal Transduction, Stem Cell Markers
Primary
925
Human
ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Alexa Fluor 488
50mM Sodium Borate with 0.05% Sodium Azide
CD8, CD8a molecule, LEU2, p32
Mouse
IgG1 Kappa
Protein G purified
RUO
Store at 4C in the dark.
Monoclonal
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alphabeta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
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