CD8 Antibody (SPM548), Alexa Fluor™ 647, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234790AF647

Catalog No. NBP234790Y

Description

CD8 Monoclonal specifically detects CD8 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Product Image.

Specifications

• Antigen: CD8
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Gene Alias: CD8, CD8a molecule, LEU2, p32
• Host Species: Mouse
• Molecular Weight of Antigen: 32 kDa
• Quantity: 0.1 mL
• Research Discipline: Adaptive Immunity, Cytokine Research, Immunology, Innate Immunity, Signal Transduction, Stem Cell Markers
• Gene ID (Entrez): 925
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
• Clone: SPM548
• Dilution: Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
• Gene Symbols: CD8A
• Immunogen: Human CD8 recombinant protein (Uniprot: P01732 )
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alphabeta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG1 κ

For Research Use Only