anti-Collagen IV alpha 1, Clone: MC4-HA, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP142233
DescriptionCollagen IV alpha 1 Monoclonal antibody specifically detects Collagen IV alpha 1 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
|Collagen IV alpha 1|
|ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500|
|The antibody reacts with the Collagen IV antigen.|
|Store at 4C. Do not freeze.|
|This monoclonal antibody reacts with native human collagen type IV, and with heat- denatured collagen IV form in ELISA and immunoblots. There is no cross-reactivity with human collagen I, II, III and V. It stains exclusively basement membranes on cryostat sections of human tissues such as kidney, liver and heart. The extent of expression of the basement membrane component type IV collagen may be correlated with the degree of differentiation of basement membrane producing neoplasms. Neoplastic cells of invasive carcinomas often lack a continuous basement membrane. In diagnostic histopathology antibodies to type IV collagen may help to distinguish between non-invasive (benign or in situ) and invasive lesions. Furthermore the antibody is important in the differential diagnosis of bullous lesions in dermatopathology. In in vitro studies with endothelial cells and smooth muscle cells the antibody is helpful in detection of production collagen type IV. This antibody reacts also with dog collagen IV on cryostate and paraffin sections.|
|ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)|
|Ascites with No Preservative|
|alpha-1 chain, arresten, COL4A1 NC1 domain, collagen alpha-1(IV) chain, collagen IV, alpha-1 polypeptide, collagen, type IV, alpha 1, Collagen-4, EC 3.4.23, EC 126.96.36.199|
|Cytoskeleton Markers, Extracellular Matrix, Stem Cell Markers|
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