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anti-Mouse Cytokeratin, HMW, Biotin, Clone: AE3, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP233170B

Catalog No. NBP233170B


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Description

Description

Cytokeratin, HMW Monoclonal antibody specifically detects Cytokeratin, HMW in Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit samples. It is validated for Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
Specifications

Specifications

Cytokeratin, HMW
AE3
Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Purified
KRT76
Human epidermal keratin was used as the immunogen for the Cytokeratin HMW AE3 antibody.
Protein G purified
RUO
Primary
51350
Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit
Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Biotin
PBS with 0.05% Sodium Azide
CK-2P, cytokeratin 2, Cytokeratin-2P, HUMCYT2A, K2P, K76, keratin 76, keratin, type II cytoskeletal 2 oral, Keratin-76, KRT2Bcytokeratin-2P, KRT2Pkeratin 2p, KRT76, Type-II keratin Kb9
Mouse
IgG1 Kappa
0.1 ml
Store at 4C in the dark.
Monoclonal
This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
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