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anti-Mouse Cytokeratin, pan, HRP, Clone: SPM115 + SPM116, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP234394H

Catalog No. NBP234394H


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Description

Description

Cytokeratin, pan Monoclonal antibody specifically detects Cytokeratin, pan in Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit samples. It is validated for Western Blot, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
Specifications

Specifications

Cytokeratin, pan
SPM115 + SPM116
Western Blot, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Purified
Human epidermal keratin
50 kDa
0.1 ml
Store at 4C in the dark.
Monoclonal
Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit
Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
HRP
PBS with No Preservative
Mouse
IgG
Protein G purified
RUO
Primary
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
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