anti-Mouse Dectin-1/CLEC7A, Alexa Fluor 700, Clone: BD6, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP121513AF700

Catalog No. NBP121513Z

Description

Dectin-1/CLEC7A Monoclonal antibody specifically detects Dectin-1/CLEC7A in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: Dectin-1/CLEC7A
• Clone: BD6
• Dilution: Flow Cytometry
• Gene Accession No.: Q9BXN2
• Gene Alias: Beta-glucan receptor, BGR, CLECSF12DC-associated C-type lectin 1, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12, C-type lectin domain family 7 member A, C-type lectin domain family 7, member A, C-type lectin superfamily member 12, dectin-1, DECTIN1CANDF4, Dendritic cell-associated C-type lectin 1, dendritic cell-associated C-type lectin-1, hDectin-1, lectin-like receptor 1
• Host Species: Mouse
• Isotype: IgG2b
• Quantity: 0.1 ml
• Research Discipline: Signal Transduction
• Primary or Secondary: Primary
• Gene ID (Entrez): 64581
• Target Species: Human

• Applications: Flow Cytometry
• Conjugate: Alexa Fluor 700
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Format: Purified
• Gene Symbols: CLEC7A
• Immunogen: NIH3T3 cells expressing full length Beta-glucan receptor
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Storage Requirements: Store at 4C in the dark.
• Monoclonal or Polyclonal: Monoclonal
• Test Specificity: NBP1-21513 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Clone BD6 recognizes betaGR-A only.

For Research Use Only