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DOG1/TMEM16A Antibody (SPM580), DyLight 488, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP234812G
Description
DOG1/TMEM16A Monoclonal specifically detects DOG1/TMEM16A in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.Specifications
DOG1/TMEM16A | |
Monoclonal | |
DyLight 488 | |
ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A | |
Mouse | |
114 kDa | |
0.1 mL | |
Primary | |
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%. | |
Store at 4C in the dark. | |
IgG1 κ |
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) | |
SPM580 | |
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen | |
ANO1 | |
Recombinant human canine1/TMEM16A protein (Uniprot: Q5XX6) | |
Protein A or G purified | |
RUO | |
55107 | |
Human | |
Purified |
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