Pepsinogen C/PGC/Progastricsin Mouse anti-Human, Clone: L10CC10, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP142322
DescriptionPepsinogen C/PGC/Progastricsin Monoclonal antibody specifically detects Pepsinogen C/PGC/Progastricsin in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin).
|PBS containing 1.0% w/v BSA with 0.09% Sodium Azide|
|EC 3.4.23, EC 220.127.116.11, FLJ99563, gastricsin, PEPC, pepsin C, Pepsinogen C, pepsinogen group II, PGII, preprogastricsin, progastricsin (pepsinogen C)|
|Store at 4C. Do not freeze.|
|The antibody is specific to human pepsinogen II with no cross reactivity to human pepsinogen I. Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and pyloric in differentiation (so called pseudopyloric metaplasia). Monoclonal antibody to pepsinogen II is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Pepsinogen II purified from human tissue was used as an immunogen.|
|Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500|
|The antibody reacts with the Pepsinogen II antigen.|
|Protein A or G purified|
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