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anti-Plasma Cell Marker, DyLight 650, Clone: SPM310, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP234407C

Catalog No. NBP234407C


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Description

Description

Plasma Cell Marker Monoclonal antibody specifically detects Plasma Cell Marker in Human, Rat (Negative) samples. It is validated for Immunohistochemistry-Paraffin.
Specifications

Specifications

Plasma Cell Marker
SPM310
Immunohistochemistry-Paraffin
Purified
Pancreatic cancer-related mucin
Protein A purified
RUO
Primary
It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues.
Immunohistochemistry (Paraffin)
DyLight 650
50mM Sodium Borate with 0.05% Sodium Azide
Mouse
IgG2a
0.1 ml
Store at 4C in the dark.
Monoclonal
Human, Rat (Negative)
Documents
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