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anti-Thyroglobulin, DyLight 488, Clone: 6E1, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP233096G

Catalog No. NBP233096G


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Description

Description

Thyroglobulin Monoclonal antibody specifically detects Thyroglobulin in Human, Mouse, Rat samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry-Paraffin.
Specifications

Specifications

Thyroglobulin
60
Western Blot, Flow Cytometry, Immunohistochemistry-Paraffin
Purified
TG
Thyroglobulin isolated from human thyroid glands was used as the immunogen for the antibody.
660 kDa
0.1 ml
Cancer, Cell Biology
Primary
7038
Human, Mouse, Rat
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin)
DyLight 488
50mM Sodium Borate with 0.05% Sodium Azide
AITD3TGN, TDH3, Tg, thyroglobulin
Mouse
IgG1 Kappa
Protein G purified
RUO
Store at 4C in the dark.
Monoclonal
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
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