anti-Tyrosinase, APC, Clone: SPM360, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP234770APC
DescriptionTyrosinase Monoclonal antibody specifically detects Tyrosinase in Human samples. It is validated for Flow Cytometry.
|Recombinant tyrosinase protein|
|Protein A purified|
|Store at 4C in the dark.|
|Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.|
|PBS with 0.05% Sodium Azide|
|CMM8, EC 188.8.131.52, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)|
|Lipid and Metabolism|
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