MRE11 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA519611
Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with mouse and rat based on sequence homology.MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintece of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3 ft.-5 ft. exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
|Synthetic peptide conjugated to KLH derived from within residues 600 - 700 of Human Mre11.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA and 0.02% sodium azide|
|ATLD, HNGS1, MRE11, MRE11B, AT-like disease; DNA recombination and repair protein; MRE11 homolog 1; MRE11 homolog A; double-strand break repair protein MRE11A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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