MRP2 Mouse anti-Human, Clone: M2I-4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA135603
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
|tissue culture supernatant with 0.7% BSA and 0.1% sodium azide|
|ABCC2, cMOAT, canalicular multi-organic anion transporter, ABC30|
|Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot|
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