MRP8 Mouse anti-Human, Clone: 7C12/4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140221
MA1-40221 detects MRP-8 from human samples. MA1-40221 has been successfully used in ELISA, flow cytometry and Western blot applications. The MA1-40221 immunogen is human MRP-8 epitope.ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
|PBS with 0.1% BSA and 0.02% sodium azide|
|Human MRP-8 epitope.|
|ELISA, Flow Cytometry, Western Blot|
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