Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MRP8 Mouse anti-Human, Clone: 7C12/4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140221

Catalog No. 01-676-561


Add to cart

Description

Description

MA1-40221 detects MRP-8 from human samples. MA1-40221 has been successfully used in ELISA, flow cytometry and Western blot applications. The MA1-40221 immunogen is human MRP-8 epitope.

ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
Specifications

Specifications

MRP8
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
Q96J66
ABCC11
Human MRP-8 epitope.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Flow Cytometry, Western Blot
7C12/4
Unconjugated
ABCC11
Liquid
Mouse
IgM
100 μg
4° C
Primary
85320
Documents
Promotions

Promotions

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit