MilliporeSigma anti-MSH2 (Ab-3), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC57100UG
Specifically detects MSH2 Clone: in Human, Mouse samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno BlottingThe MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma, while germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids.
|Immuno Blotting, Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation|
|In 0.05M sodium phosphate buffer, 50% glycerol.|
|Recognizes the ∽100kDa MSH2 protein in HCT116 and SW480 cells and in colon tissue.|
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