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MSH2 Mouse anti-Human, Clone: 2MSH01, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112621

Catalog No. 01-674-005


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Description

Description

A suggested positive control for this product is tonsil tissue.

MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma. Defects in MSH2 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, domitly inherited disease associated with marked increase in cancer susceptibility. it is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.
Specifications

Specifications

MSH2
Monoclonal
Unconjugated
MSH2
Liquid
MSH2
Recombit human MSH2 protein.
500 μL
4° C, do not freeze
Primary
4436
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
2MSH01
tissue culture supernatant with 0.09% sodium azide
P43246
COCA1, FCC1, HNPCC, HNPCC1
Mouse
IgG1
RUO
Antibody
Monoclonal
Human
Documents
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