MSH2 Mouse anti-Human, Clone: 2MSH01, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112621
A suggested positive control for this product is tonsil tissue.MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma. Defects in MSH2 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, domitly inherited disease associated with marked increase in cancer susceptibility. it is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.
|Recombit human MSH2 protein.|
|4° C, do not freeze|
|Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|tissue culture supernatant with 0.09% sodium azide|
|COCA1, FCC1, HNPCC, HNPCC1|
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