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MSH3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527864

Catalog No. PIPA527864


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Description

Description

PA5-27864 targets MSH3 in WB applications and shows reactivity with Human samples. The PA5-27864 immunogen is recombit fragment corresponding to a region within amino acids 59 and 349 of Human MSH3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Specifications

Specifications

MSH3
Polyclonal
Unconjugated
MSH3
Liquid
MSH3
Recombit fragment corresponding to a region within amino acids 59 and 349 of Human MSH3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.83 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P20585
DUP, MRP1, DNA mismatch repair protein Msh3, divergent upstream protein, hMSH3, mismatch repair protein 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4437
Documents
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