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MSL2 Mouse anti-Human, Clone: 3A4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA522114

Catalog No. PIMA522114


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Description

Description

Peptide Sequence: GQRCPCYSNR KACLDCICRG CQNSYMANGE KKLEAFAVPE KALEQTRLTL GINVTSIAVR NASTSTSVIN VTGSPVTTFL AASTHDDKSL DEAIDMRF

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at  ft.Lys-35 ft. (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at  ft.Lys-4 ft. (H3K4me) and  ft.Lys-79 ft. (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Specifications

Specifications

MSL2
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
Q9HCI7
MSL2
MSL2 (NP_060603, 478 a.a. ∽ 575 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA
3A4
Unconjugated
MSL2
Liquid
Mouse
IgG1, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
55167
Documents
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