MSL2 Mouse anti-Human, Clone: 3A4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA522114
Peptide Sequence: GQRCPCYSNR KACLDCICRG CQNSYMANGE KKLEAFAVPE KALEQTRLTL GINVTSIAVR NASTSTSVIN VTGSPVTTFL AASTHDDKSL DEAIDMRFComponent of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at ft.Lys-35 ft. (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at ft.Lys-4 ft. (H3K4me) and ft.Lys-79 ft. (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
|PBS with no preservative; pH 7.4|
|MSL2 (NP_060603, 478 a.a. ∽ 575 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
|-20° C, Avoid Freeze/Thaw Cycles|
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