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MST3 Mouse, Unlabeled, Clone: 47, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611056

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Catalog No. BDB611056

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase [PAK]) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42 binding domain. Members of the second class lack GTPase binding sites, but are similar to the former class throughout the catalytic domain. The latter class includes GC kinase, HPK, KHS, KRS1 & 2, MST1, 2, & 3, and SOK-1. MST3 (Mammalian Sterile Twenty-like) is a ubiquitous cytoplasmic kinase that contains an N terminal kinase domain and a C-terminal regulatory domain. It shares extensive sequence similarity with SOK-1 and is similarly autophosphorylated and activated. MST3 remains distinct in that it prefers Mn2+ to Mg2+ as a divalent cation and uses GTP and ATP as phosphate donors. It does not respond to a variety of mitogenic and stress stimuli and fails to activate known mammalian MAPK pathways. Although its function is undefined, MST3 may function in a novel intracellular signaling pathway.

Immunofluorescence, Western Blotting

Specifications

Specifications

MST3
47
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human MST3 aa. 275-393
50μg
Cell Biology
Monoclonal
Documents
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