MTA2 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141581
This antibody is predicted to react with mouse, rat, canine, bovine, and xenopus samples based on sequence homology. Suggested positive control: Jurkat cell lysate.MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependant transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.
|Synthetic peptide corresponding to residues 650-700 of human MTA2.|
|Antigen affinity chromatography|
|Human, Non-human Primate|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|DKFZp686F2281, MTA1L1, PID|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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