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MTA2 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141581

Catalog No. 01-675-200


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Description

Description

This antibody is predicted to react with mouse, rat, canine, bovine, and xenopus samples based on sequence homology. Suggested positive control: Jurkat cell lysate.

MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependant transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.
Specifications

Specifications

MTA2
Polyclonal
Unconjugated
MTA2
Liquid
MTA2
Synthetic peptide corresponding to residues 650-700 of human MTA2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Non-human Primate
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
O94776
DKFZp686F2281, MTA1L1, PID
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9219
Documents
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