MTBP Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA519979
In Western blot applications, this antibody detects a band at ~104kDa. A suggested positive control is K562 cell lysate. PA5-19979 can be used with blocking peptide PEP-0103.The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.
|PBS with 0.02% sodium azide|
|MDM2BP; MDM2 (mouse double minute 2)-binding protein, 104kD; hMTBP; mdm2-binding protein|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|A synthetic peptide corresponding to amino acids 122 to 139 of human MTBP|
|Antigen affinity chromatography|
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