MTSS1 Rabbit anti-Canine, Chicken, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523200
DescriptionMetastasis suppressor protein 1 (MTSS1) [MIM, “missing in metastasis”], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains an actin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
|Synthetic peptide (176 LEETEKQAVRKALIEERGRFC 196) of MTSS1 protein.|
|Canine, Chicken, Human, Mouse, Non-human primate, Rat|
|PBS with 0.05% BSA and 0.05% sodium azide|
|MIM, MIMA, MIMB, metastasis suppressor YGL-1, metastasis suppressor protein 1, missing in metastasis protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|211401, 362918, 420336, 482037, 9788|
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