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MUC4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523077

Catalog No. PIPA523077


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Description

Description

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predomitly affected in Asian diseases – Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.
Specifications

Specifications

MUC4
Polyclonal
Unconjugated
MUC4
Liquid
MUC4
A synthetic peptide made to an internal region of the human MUC4 protein (within residues 1950-2100).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.56 mg/mL
PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide
Q99102, Q8JZM8
ASGP, HSA276359, MUC-4, ascites sialoglycoprotein, mucin 4, tracheobronchial, mucin-4, pancreatic adenocarcinoma mucin, testis mucin, tracheobronchial mucin
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
140474, 4585
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