TRPML1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific OSR00050W

Catalog No. OSR00050W

Description

Glycerol (1:1) may be added for additional stability. Reconstitute in 100 μL of sterile water. OSR00050W can be used with blocking peptide GSM00003P.

Polycystin cation channel contains the cation channel region of PKD1 and PKD2 proteins; pfam08016. Cationic channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis. Forms multimeric complexes. Widely expressed, with the highest expression in brain, liver and kidney. MISCELLANEOUS: Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels.

Specifications

• Antigen: TRPML1
• Classification: Polyclonal
• Gene: Mcoln1
• Gene Alias: Mucolipin-1, Mucolipidin, Mcoln1, Mucolipin 1, MCLN1, TRPML1, MGC7172, 2210015I05Rik
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q99J21
• Gene Symbols: MCOLN1
• Immunogen: A synthetic peptide from aa 150-210 of mouse Mucolipin 1 conjugated to an immunogenic carrier protein
• Regulatory Status: RUO
• Gene ID (Entrez): 94178
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized