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MUNC18 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1742

Catalog No. PA1742

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PA1-742 detects Munc-18 from human, rat and mouse tissues. PA1-742 has been successfully used in Western blot, immunohistochemistry, and immunoprecipitation procedures. By Western blot, this antibody detects an ~67 kDa protein representing Munc-18 from rat and mouse whole brain extract. PA1-742 immunizing peptide corresponds to amino acid residues 58-70 from human Munc-18. This sequence is completely conserved between human, mouse, rat, bovine, and canine Munc-18. PA1-742 immunizing peptide (Cat. No. PEP-067) is available for use in neutralization and control experiments.

Munc-18 is a cytosolic brain protein of ~67 kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. Functional interactions have been demonstrated to exist between Munc-18, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin. Munc-18 is the mammalian homologue of the C. elegans gene unc-18. Mutations in Munc-18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Munc-18 thus appears to be required by the synaptic vesicle fusion complex. Two Munc-18 isoforms have recently been identified. Munc-18-1 has been shown to be primarily expressed in brain, while Munc-18-2 is expressed in most tissues.


Synthetic Peptide: V(58) E D I N K R R E P I P S(70)
Antigen affinity chromatography
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P61764, O08599, P61765
MGC146482, hunc18, munc18-1, rbsec1, rop, unc18
100 μg
-20° C, Avoid Freeze/Thaw Cycles
20910, 25558, 6812
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