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GnRH1 Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1120

Catalog No. PA1120

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Description

Description

PA1-120 detects gonadotropin releasing hormone (GnRH) in mouse brain. PA1-120 has been successfully used in immunofluorescence and immunohistochemistry procedures. Immunofluorescent staining of GnRH in mouse embryo brain tissue using PA1-120 results in staining of neurons in the rostral forebrain. In immunohistochemical procedures, 4% paraformaldehyde is recommended as a fixative. The PA1-120 immunogen is a synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH. This peptide (Cat. No. PEP-168) is available for use in neutralization and control experiments.

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.   Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
Specifications

Specifications

GnRH1
Polyclonal
Unconjugated
Gnrh1
Liquid
GNRH1
Synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH.
Protein G
RUO
Antibody
Polyclonal
Mouse
Immunofluorescence, Immunohistochemistry
1 mg/mL
PBS with 0.05% sodium azide
P13562
Gonadotropin Releasing Hormone, LHRH, Luteinizing Hormone Releasing Hormone
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14714
Documents
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