CHRM2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA123537
PA1-23537 detects Muscarinic Acetylcholine Receptor M2 in human samples. PA1-23537 has been successfully used in immunohistochemistry (paraffin) procedures. The PA1-23537 immunogen is a synthetic peptide, conjugated to KLH.Muscarinic cholinergic receptor 2 is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer ft.s disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|PBS with 0.01% sodium azide; pH 7.7|
|Synthetic peptide, conjugated to KLH|
|Antigen affinity chromatography|