MBNL1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA529541
PA5-29541 targets Muscleblind-like 1 in WB applications and shows reactivity with Human samples. The PA5-29541 immunogen is recombit protein fragment corresponding to a region within amino acids 81 and 326 of Human Muscleblind-like 1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5 ft.-YGCU(U/G)Y-3 ft.consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
|Recombit protein fragment corresponding to a region within amino acids 81 and 326 of Human Muscleblind-like 1|
|Antigen affinity chromatography|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|EXP, EXP35, EXP40, EXP42, MBNL, muscleblind-like protein 1, triplet-expansion RNA-binding protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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