MYBPC2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520917
A suggested positive control is mouse skeletal muscle tissue lysate. PA5-20917 can be used with blocking peptide PEP-1031.Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the fast-type isoform designated MYBPC2. Both the fast-type and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. MYBPC2 is typically required for strong contractions and functions under anaerobic conditions. It is more similar to the cardiac isoform (MYBPC3) than to the slow-type isoform (MYBPC1) in terms of pCa50-indexed force development, length-independent cooperativity and length dependent activation. It has been suggested that in cardiac and fast muscle MYBPC2 contributes to an internal load, possibly by binding to actin via its N-terminal region.
|A 15 amino acid peptide near the carboxy terminus of human MYBPC2.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|MYBPC, MYBPCF; C-protein, skeletal muscle fast isoform; fast MyBP-C; fast-type muscle myosin-binding-protein C; myosin-binding protein C, fast-type|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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