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MBP Mouse anti-Goat, Human, Mouse, Non-human primate, Ovine, Rabbit, Rat, Clone:, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110837

Catalog No. 01-671-865


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Description

Description

MA1-10837 detects Myelin Basic Protein from human, non-human primate, rabbit, sheep, goat, rat, and mouse samples. MA1-10837 has been successfully used in ELISA, Western blot, and immunohistochemistry applications. The MA1-10837 immunogen is purified human myelin basic protein.

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Specifications

Specifications

MBP
Monoclonal
Unconjugated
MBP
Liquid
MBP
Purified human myelin basic protein.
Protein G
RUO
Antibody
Monoclonal
Goat, Human, Mouse, Non-human primate, Ovine, Rabbit, Rat
ELISA, Immunohistochemistry, Western Blot
2.9 mg/mL
PBS with no preservative; pH 7.4
P02686, P25274, P02688, P04370
MBP
Mouse
IgG2b
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
106503529, 17196, 100344447, 24547, 101109407, 4155
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