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MBP Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118324

Catalog No. 01-670-577



Description

Description

PA1-18324 detects MBP from human and rat samples. PA1-18324 has been successfully used in immunohistochemistry staining of MBP in abnormal oligodendrocytic process and cell bodies in demyelinating areas. This antibody recognizes only areas of myelin degeneration when tested in injured spinal cord and lesioned sciatic nerve, and also stains discrete white matter in the brain of multiple system atrophy. The PA1-18324 immunogen is a synthetic peptide corresponding to residues Y(68) G S L P Q K S Q R S Q D E N P V V(86) of guinea pig MBP, conjugated to KLH. Reconstitute with 100 µL of distilled water.

Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein. MBP is an  ft.intrinsically unstructured ft. protein with a high proportion (approximately 75%) of random coil, but postulated to have core elements of beta-sheet and alpha-helix. MBP is a major protein in CNS myelin and is expressed specifically in the nervous system.
Specifications

Specifications

MBP
Polyclonal
whole serum with no preservative
P02686, P02688
MBP
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry
Unconjugated
MBP
Lyophilized
MBP
Synthetic peptide corresponding to residues Y(68) G S L P Q K S Q R S Q D E N P V V(86) of guinea pig MBP, conjugated to KLH.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
24547, 4155
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