anti-Myelin Basic Protein Polyclonal, Thermo Scientific™

Myelin Basic Protein Polyclonal Ab PA1-10008 from Thermo Scientific™ detects Myelin Basic Protein in Bv, Hu, Ms and Rt samples, and is validated for ICC, IF, IHC and WB

Manufacturer: Invitrogen PA110008

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Catalog No. 01-670-265

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    Specifications

    Antigen Myelin Basic Protein
    Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry,Western Blot
    Conjugate Unlabeled
    Cross Reactivity Bovine,Human,Mouse,Rat
    Format Purified
    Formulation 100μL purified antibody in PBS and 10mM sodium azide
    Gene Accession No. P02686, P02687, P02688, P04370, P15720, P81558, P83487
    Gene Alias MGC99675, MBP
    Gene Symbols MBP
    Host Species Chicken
    Immunogen Full length purified myelin basic protein isolated from cow nerve
    Isotype IgY
    Quantity 100μL
    Species Reactivity Bovine, Human, Mouse, Rat
    Storage Requirements avoiding freeze/thaw cycles.
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 100063306, 17196, 24547, 396217, 414286, 4155, 618684

    Myelin Basic Protein Polyclonal Ab PA1-10008 from Thermo Scientific™ detects Myelin Basic Protein in Bv, Hu, Ms and Rt samples, and is validated for ICC, IF, IHC and WB

    Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago. The protein is made by oligodendrocytes in the central nervous system so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells. In the central nervous system there are three different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5 and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typical show two bands on Western blots, one at about 22kDa and another at about 18 kDa.
    Host Species: Chicken
    Cross Reactivity: Bovine, Human, Mouse, Rat
    Isotype: IgY
    Immunogen: Full length purified myelin basic protein isolated from cow nerve
    Formulation: 100µL purified antibody in PBS and 10mM sodium azide
    Synonyms: MGC99675, MBP
    Uniprot Accession: P02686, P02687, P02688, P04370, P15720, P81558, P83487
    Entrez GeneID: 100063306, 17196, 24547, 396217, 414286, 4155, 618684
    Gene Symbol: MBP
    In Western blot using rat spinal cord whole tissue homogenates, this antibody detects all isotypes of MPB, resulting in bands at ~21.5kDa, 18.5kDa, 17kDa and 14kDa.
    References:
    Test: ICC, Dilution: 1:50, Species: Rt, Reference: Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+ channels. (Oct 2014) Dev. Growth Differ., Vol: 56, 8, 583-94, Teh DB,Ishizuka T,Yawo H; Pubmed ID: 25283796

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