Myeloperoxidase Polyclonal Antibody, Invitrogen™

Myeloperoxidase Antibody, PA1-18308, from Invitrogen™. Species Reactivity: Human; Applications: Immunohistochemistry (Paraffin, Frozen), Western Blot.

Manufacturer: Invitrogen PA118308

Catalog No. 01-670-561

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    Specifications

    Formulation 250μg purified antibody (1mg/mL) and no preservative
    Gene ID (Entrez) 4353
    Applications Frozen),Immunohistochemistry (Paraffin,Western Blot
    Gene Accession No. P05164
    Gene Alias MPO
    Gene Symbols MPO
    Species Reactivity Human
    Storage Requirements Avoid Freeze/Thaw Cycles
    Isotype IgG
    Quantity 250μg
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Conjugate Unlabeled
    Cross Reactivity Human
    Antigen Myeloperoxidase
    Format Purified
    Host Species Rabbit
    Immunogen Myeloperoxidase isolated from human polymorphonuclear leucocytes.

    Myeloperoxidase Antibody, PA1-18308, from Invitrogen. Species Reactivity: Human; Applications: Immunohistochemistry (Paraffin, Frozen), Western Blot.

    Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW ~59 - 64 kDa) and two unglycosylated beta chains (MW ~14 kDa) with total MW ~150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.
    Host Species: Rabbit
    Cross Reactivity: Human
    Isotype: IgG
    Immunogen: Myeloperoxidase isolated from human polymorphonuclear leucocytes.
    Formulation: 250µg purified antibody (1mg/mL) and no preservative
    Synonyms: MPO
    Uniprot Accession: P05164
    Entrez GeneID: 4353
    Gene Symbol: MPO
    PA1-18308 detects Myeloperoxidase from human samples. PA1-18308 has been successfully used in immunohistochemistry (paraffin and frozen) and Western blot procedures. The PA1-18308 immunogen is Myeloperoxidase isolated from human polymorphonuclear leucocytes. Reconstitute with 250 ul of distilled water.
    References:
    Test: IHC, Species: Hu, Reference: Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. (2011 Jun 20) Arthritis Res Ther, Vol: 13, 3, R95, Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Thiel A, Radbruch A, Loddenkemper C, Sieper J; Pubmed ID: 21689402

    • Purchase any three Invitrogen™ Antibodies and receive a fourth antibody at no additional cost. To take advantage of this offer, apply for the NLSU program.

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