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MYO1A Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514229

Catalog No. PIPA514229

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

MYO1A belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding  ft.neck ft. region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein envelops an actin core bundle that, by comparison, is static in structure.
Specifications

Specifications

MYO1A
Polyclonal
PBS with 0.09% sodium azide
Q9UBC5
Myosin-Ia; Brush border myosin I; BBM-I; BBMI; Myosin I heavy chain; MIHC; MYHL; MYO1A
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4640
Flow Cytometry, Western Blot
Unconjugated
MYO1A
Liquid
MYO1A
KLH conjugated synthetic peptide between 276-304 amino acids from the central region of human MYO1A
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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