Myogenin Mouse anti-Human, Mouse, Rat, Clone: 5FD, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141042
Suggested positive control: Rh-30.Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Transfection of myogenin and other family members into a variety of non-muscle cells has been shown to either convert these cells to myogenic cells, or to transcriptionally activate a set of otherwise unexpressed muscle-specific genes. In addition to activating muscle specific genes, members of the MyoD family members activate their own transcription and transactivate the transcription of other MyoD family members.
|PBS with 0.05% sodium azide|
|P15173, P12979, P20428|
|MYF4, MYOGENIN, bHLHc3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|17928, 29148, 4656|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|Recombit GST tagged fusion protein corresponding to residues 30-224 of rat myogenin.|
|Human, Mouse, Rat|
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