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Myogenin Mouse anti-Human, Mouse, Rat, Clone: 5FD, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141042

Catalog No. 01-676-450


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Description

Description

Suggested positive control: Rh-30.

Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6).  MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif.  MyoD family members share about 80% amino acid homology in their bHLH motifs.  Transfection of myogenin and other family members into a variety of non-muscle cells has been shown to either convert these cells to myogenic cells, or to transcriptionally activate a set of otherwise unexpressed muscle-specific genes. In addition to activating muscle specific genes, members of the MyoD family members activate their own transcription and transactivate the transcription of other MyoD family members.
Specifications

Specifications

Myogenin
Monoclonal
1 mg/mL
PBS with 0.05% sodium azide
P15173, P12979, P20428
MYF4, MYOGENIN, bHLHc3
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
17928, 29148, 4656
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
5FD
Unconjugated
MYOG
Liquid
MYOG
Recombit GST tagged fusion protein corresponding to residues 30-224 of rat myogenin.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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