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MYO7A Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1936

Catalog No. PA1936


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Description

Description

PA1-936 detects myosin VIIa from mouse tissues as well as recombit protein. PA1-936 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~220 kDa protein representing myosin VIIa from mouse testes preparations. PA1-936 detects recombit mouse myosin VIIa overexpressed in Sf9 insect cell lysate. PA1-936 immunizing peptide corresponds to amino acid residues 16-31 from mouse myosin VIIa. This sequence is completely conserved in mouse, porcine, and human myosin VIIa. PA1-936 immunizing peptide (Cat. No. PEP-045) is available for use in neutralization and control experiments.

Myosin VIIa is a member of the myosin superfamily of actin-based motor proteins. Defects in the myosin VIIa gene are responsible for hearing impairment in shaker-1 (sh1) mice and causes Usher syndrome IB in humans. Usher syndrome associates congenital deafness, vestibular dysfunction, and retinitis pigmentosa and is the most common form of combined deafness and blindness. Structural features of myosin VIIa protein include an ATP binding N-terminal motor domain, a central region which possess five light-chain binding (IQ) motifs, and a C-terminal domain with three myosin tail homology (MyTH4) and talin-like homology regions.
Specifications

Specifications

MYO7A
Polyclonal
Unconjugated
Myo7a
Liquid
MYO7A
Synthetic Peptide: S(16) G Q E F D V P I G A V V K L C(31)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P97479
MyO VIIa
Rabbit
IgG
200 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
17921, 266714
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