Myosin Vb/Myr 6 Mouse anti-Rat, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611608
Myosins are proteins that form oligomers consisting of two heavy chains and varying numbers of light chains. Many classes of myosin superfamily proteins which have similar N-terminal motor domains but divergent C-terminal domains have been characterized. Class V myosins interact via their C-terminal tails with specific proteins involved in organelle transport. In vertebrates, the myosin V family includes mouse myosin Va (dilute myosin) and Vb, rat myosin Vb (myosin from rat 6; myr 6), and chicken p190. Myr 6 includes an N-terminal globular domain, six IQ motifs in the neck region, two coiled-coil domains on each side (cc) of a PEST calpain cleavage region, and a C-terminal tail that is homologous to dilute myosin, AF-6, and GAD. Myr 6 is expressed highly in mouse heart, kidney, testis, liver, and lung. In rat brain, it is expressed highly in dentate gyrus,medial mamillary nuclei, amygdala, and choroid plexus. The tail region of myr 6 interacts with the C-terminal domain of BERP, a RING-B-box-coiled-coil protein that has been implicated in PC12 cell neurite outgrowth. Thus, myr 6 may function in the transport of organelles in a variety of neural and non-neuronal tissues.
Host Species: Mouse
Species Reactivity [for Features Main]: Rat
Immunogen: Rat Myr6 aa. 940-1051
Immunofluorescence, Western Blotting
|Myosin Vb/Myr 6|
|Rat Myr6 aa. 940-1051|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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