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NALP10 Mouse anti-Human, Mouse, Rat, Clone: 578502, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524260

Catalog No. PIMA524260


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Description

Description

In direct ELISAs, no cross-reactivity with recombit human (rh) NALP1 (aa 1-323), rhNALP1 (aa 1331-1429), rhNALP2 (aa 1-208), rhNALP3 (aa 3-223), rhNALP3 (aa 540-689), rhNALP5 (aa 469-635), rhNOD1 (aa 830-953), or rhNOD2 (aa 230-450) is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
Specifications

Specifications

NALP10
Monoclonal
0.2 mg/mL
PBS with 5% trehalose and No Preservative
Q86W26, Q8CCN1
CLR11.1, NALP10, NOD8, PAN5, PYNOD, NACHT, LRR and PYD domains-containing protein 10, NACHT, leucine rich repeat and PYD containing 10, nucleotide-binding oligomerization domain protein 8, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
Mouse
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
244202, 293426, 338322
Western Blot
578502
Unconjugated
NLRP10
Lyophilized
NLRP10
E. coli-derived recombit human NLRP10/Pynod/NALP10 Met386-Ile655
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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