NALP10 Mouse anti-Human, Mouse, Rat, Clone: 578502, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524260
In direct ELISAs, no cross-reactivity with recombit human (rh) NALP1 (aa 1-323), rhNALP1 (aa 1331-1429), rhNALP2 (aa 1-208), rhNALP3 (aa 3-223), rhNALP3 (aa 540-689), rhNALP5 (aa 469-635), rhNOD1 (aa 830-953), or rhNOD2 (aa 230-450) is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
|PBS with 5% trehalose and No Preservative|
|CLR11.1, NALP10, NOD8, PAN5, PYNOD, NACHT, LRR and PYD domains-containing protein 10, NACHT, leucine rich repeat and PYD containing 10, nucleotide-binding oligomerization domain protein 8, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10|
|-20° C, Avoid Freeze/Thaw Cycles|
|244202, 293426, 338322|
|E. coli-derived recombit human NLRP10/Pynod/NALP10 Met386-Ile655|
|Human, Mouse, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok