NALP10 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521025
A suggested positive control is human brain tissue lysate. PA5-21025 can be used with blocking peptide PEP-1139.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
|A 14 amino acid peptide near the amino terminus of human NALP10.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CLR11.1, NALP10, NOD8, PAN5, PYNOD; NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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