NALP12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521027
A suggested positive control is human brain tissue lysate. PA5-21027 can be used with blocking peptide PEP-1141.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
|An 18 amino acid peptide near the amino terminus of human NALP12.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NACHT, leucine rich repeat and PYD containing 12; PYRIN-containing APAF1-like protein 7; monarch 1; monarch-1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; regulated by nitric oxide|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|292541, 378425, 91662|
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