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NALP12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521027

Catalog No. PIPA521027


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-21027 can be used with blocking peptide PEP-1141.

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Specifications

Specifications

NALP12
Polyclonal
Unconjugated
NLRP12
Liquid
NLRP12
An 18 amino acid peptide near the amino terminus of human NALP12.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P59046, E9Q5R7
CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NACHT, leucine rich repeat and PYD containing 12; PYRIN-containing APAF1-like protein 7; monarch 1; monarch-1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; regulated by nitric oxide
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
292541, 378425, 91662
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