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NALP2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523315

Catalog No. PIPA523315


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Description

Description

NALP2 is a 1062 amino acid containing cytosolic protein, belonging to the NLRP family and is characterized by the presence of an N-terminal pyrin domain (PYD), eight leucine rich repeats and a NACHT domain. This protein is involved in the activation of caspase-1 by Toll-like receptors and may also be involved in protein complexes that activate proinflammatory caspases. The DAPIN domain of NALP2 helps in suppressing TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. NALP2 is known to interact with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. It is widely expressed in most of the tissues with high expression in lung, placenta and thymus, low expression in ovary, intestine and brain and variably in some cancer cell lines. 
Specifications

Specifications

NALP2
Polyclonal
Unconjugated
NLRP2
Liquid
NLRP2
Synthetic peptide (1044 DTEKHHPWAERPSSHD 1059) of NALP2  protein.
Protein A
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q9NX02
CLR19.9, NALP2, NBS1, PAN1, PYPAF2, NACHT, LRR and PYD containing protein 2, NACHT, LRR and PYD domains-containing protein 2, NACHT, leucine rich repeat and PYD containing 2, PYRIN domain and NACHT domain-containing protein 1, PYRIN-containing APAF1-like protein 2, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2, nucleotide-binding site protein 1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
55655
Documents
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