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NALP5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521021

Catalog No. PIPA521021


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Description

Description

A suggested positive control is mouse brain tissue lysate. PA5-21021 can be used with blocking peptide PEP-1135.

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombit NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Specifications

Specifications

NALP5
Polyclonal
Unconjugated
NLRP5
Liquid
NLRP5
A 14 amino acid peptide near the carboxy terminus of human NALP5.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P59047, Q9R1M5
CLR19.8, MATER, NALP5, PAN11, PYPAF8; NACHT, LRR and PYD domains-containing protein 5; NACHT, leucine rich repeat and PYD containing 5; mater protein homolog; maternal antigen that embryos require; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
126206, 23968, 308325
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