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NALP6 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521022

Catalog No. PIPA521022


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Description

Description

A suggested positive control is human heart tissue lysate. PA5-21022 can be used with blocking peptide PEP-1136.

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
Specifications

Specifications

NALP6
Polyclonal
Unconjugated
NLRP6
Liquid
NLRP6
A 16 amino acid peptide near the amino terminus of human NALP6.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P59044, Q91WS2
CLR11.4, NALP6, PAN3, PYPAF5; NACHT, LRR and PYD containing protein 6; NACHT, LRR and PYD domains-containing protein 6; NACHT, leucine rich repeat and PYD containing 6; PYRIN-containing APAF1-like protein 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
101613, 171389
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