NALP7 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521023
A suggested positive control is human brain tissue lysate. PA5-21023 can be used with blocking peptide PEP-1137.NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1-b secretion and is a feedback regulator of interleukin-1-b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
|An 18 amino acid peptide near the amino terminus of human NALP7.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains-containing protein 7; NACHT, leucine rich repeat and PYD containing 7; PYRIN-containing Apaf1-like protein 3; nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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