NANOS1 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523379
DescriptionNANOS1 is a protein that belongs to the os family. The C terminus contains a conserved RNA-binding domain that consists of two zinc fingers. os-type zinc finger is composed of two C2HC motifs, each motif binds one molecule of zinc. It is essential for the translation repression activity of the protein. The zinc finger region of NANOS1 shares 62% identity with the zinc finger region of Drosophila os. It is required for the development of germ stem cells in both the sexes. It may regulate translation of specific mRNAs by forming a complex with PUM2. A region of PUM2 that include the RNA-binding domain and 155 upstream amino acids interacted with the zinc finger domain of NANOS1. NANOS1 is expressed during meiosis in spermatocytes but is absent in late post meiotic-stage germ cells. Northern blot analysis shows its almost exclusive expression on testis. It is also expressed in fetal testis and fetal ovary. It is essential for both establishing and maintaining germline stem cells by preventing their precocious entry into oogenesis. Removing NANOS from germline stem cells or their precursors, the primordial germ cells, causes both cell types to differentiate into germline cysts.
|Synthetic peptide (54 TKAVDGEPRFGC 65) of NANOS1 protein.|
|Antigen affinity chromatography|
|Human, Non-human Primate|
|PBS with 0.05% BSA and 0.05% sodium azide|
|RP11-498J9.3, NOS1, EC_Rep1a, NOS-1, os homolog 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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