NANOS1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520556
A suggested positive control is SK-N-SH cell lysate. PA5-20556 can be used with blocking peptide PEP-0676.os1 is one of three known mammalian homologs to the Drosophila gene os. os1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either os2 or os3, mice lacking the os1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of os1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on os1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of os1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting os1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.
|A 17 amino acid peptide from near the amino terminus of human os1.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-498J9.3, NOS1; EC_Rep1a; NOS-1; os homolog 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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