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NANOS2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520536

Catalog No. PIPA520536


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Description

Description

A suggested positive control is human testis tissue lysate. PA5-20536 can be used with blocking peptide PEP-0656.

os is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, os represses apoptosis during development to ensure proper germ-line development. Unlike os1 whose expression in mice is dispensable, the os2 and os3 proteins are required for germ cell development. os2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while os3-null PGCs are lost during the migration stage regardless of sex. os2 and os3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of os2 can at least partially replace os3 function in a os3-null background. os3 expression can not rescue os2-null defects.
Specifications

Specifications

Nanos2
Polyclonal
Unconjugated
NANOS2
Liquid
NANOS2
A 13 amino acid peptide near the carboxy terminus of the human os2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P60321, P60322
NOS2; NOS-2; os homolog 2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
339345, 365213, 378430
Documents
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