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β-NAP Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610892

Catalog No. BDB610892


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Description

Description

Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins ( γ, α , δ , or ε and β 1, β 2, β σ 2, σ 3, or σ 4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. Two AP-3 complexes have been identified as a neuronal complex and a ubiquitously-expressed complex. The neuronal AP-3 complex contains Adaptin β 3B ( β -NAP), which has 61% identify with Adaptin β 3A found in the ubiquitously-expressed AP-3 complex, and 30% identity with Adaptins β 1 and β 2 found in the AP-1 and AP-2 complexes.

Specifications

Specifications

β-NAP
18
Unconjugated
Affinity Purified
Human β-NAP aa. 839-1036
50μg
Cell Biology
Primary
Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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