β-NAP Mouse, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610892
Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins ( γ, α , δ , or ε and β 1, β 2, β σ 2, σ 3, or σ 4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. Two AP-3 complexes have been identified as a neuronal complex and a ubiquitously-expressed complex. The neuronal AP-3 complex contains Adaptin β 3B ( β -NAP), which has 61% identify with Adaptin β 3A found in the ubiquitously-expressed AP-3 complex, and 30% identity with Adaptins β 1 and β 2 found in the AP-1 and AP-2 complexes.
|Human β-NAP aa. 839-1036|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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