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KLRB1 Mouse anti-Mouse, Clone: 1C10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112555

Catalog No. 01-674-341


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Description

Description

Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.
Specifications

Specifications

KLRB1
Monoclonal
Unconjugated
Klrb1a
Liquid
KLRB1A
Lymphokine-activated killer Cells.
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Immunoprecipitation, Western Blot
1C10
PBS with 0.08% sodium azide
P27811
Ly55a, NKR-P1A, NKRP12, Nkrp1-a, Nkrp1a
Mouse
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
17057
Documents
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